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Funding and Support

Letter of Support

Cite The Grant

NIH Funding Acknowledgment on ACTRI Publications/Projects 

All publications/projects resulting from the utilization of any ACTRI resources are required to: 

  • Credit the CTSA grant 
  • Comply with NIH Public Access Policy and be assigned a PMCID 


Frequently Asked Questions 

  • Who needs to cite the CTSA grant? 
  • PIs and researchers who are Pilot grant awardees, KL2 scholars, ACTRI voucher awardees, and/or utilize ACTRI services are required to cite the CTSA grant (UL1 TR001442) on any resulting publications they are author or co-author for 


  • How do I cite the CTSA grant? 
  • Please use the following language to acknowledge the CTSA grant in publications: 
  • “The project described was partially supported by the National Institutes of Health, Grant UL1TR001442. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.” 
  • For KL2 scholars, they are also required to cite the KL2 grant, using the following language: 
  • “The project described was partially supported by the National Institutes of Health, Grant UL1TR001442 and KL2TR001444. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.”  


For any questions, please reach out to 


ACTRI Summary for Grant Proposals

Vision and Mission

The Vision of UC San Diego Altman Clinical and Translational Research Institute (ACTRI) is to translate scientific discoveries into improved health.

Our Mission is to provide research resources, training, and collaboration opportunities for ACTRI scientists, health care providers, and the community.

Established in 2010, ACTRI provides infrastructure and support for basic, translational, and clinical research throughout the San Diego region; expedites the translation of discoveries into therapies; and facilitates the training and education of the next generation of researchers. We carry out our activities in collaboration with institutional and corporate partners.

ACTRI now has more than 1,400 members, with affiliations that stretch across UC San Diego and San Diego State University to the Sanford Burnham Prebys Medical Discovery Institute and the Salk Institute, to Rady Children’s Hospital and the VA San Diego Health Care System, to nonprofit and biotech/pharma.

ACTRI is partially funded by the National Center for Advancing Translational Sciences, a component of the National Institutes of Health, through a competitive, five-year Clinical and Translational Science Award (CTSA), making us part of the national CTSA Consortium.

The Institute is located in the new Altman CTRI building at UC San Diego near Thornton Pavilion in La Jolla. The facility houses ACTRI’s administrative offices with approximately 50 staff members, as well as the ACTRI clinic and labs. This seven-story, $269 million facility serves as a bridge between UC San Diego’s clinical and research enterprises.

ACTRI provides assistance with proposal development, study design, regulatory issues and submissions, biostatistics and informatics, ethics consultation, clinical trial coordination, genomics technologies, a biorepository, facilitation with an affiliated laboratory network, and training for medical students and early career investigators. More than 200 clinical trials are run through ACTRI every year.

ACTRI Organizational Structure

Six ACTRI Units enable us to achieve our mission: the Center for Clinical Research Services; Biomedical Informatics; Translational Research Technology; Community Engagement; Education, Training and Career Development; and the Translational Research Alliance.

Center for Clinical Research (CCR)
Director: Mark Wallace, MD

  • Research Design and Biostatistics assists with the planning, conduct, analysis, and reporting of clinical trials; studies involving epidemiology, populations, and the risk of disease; translational research; scientific computing for data analysis and scientific graphics; analysis of high-dimensional data generated by –omics fields and imaging research; database design and management; IND protocols and other technical issues; and revisions of grant applications
  • Ethics Support provides education and training to ensure that researchers are aware of safeguards and controls to protect human subjects. These programs include daylong ethics train-the-trainer courses for ACTRI faculty, focusing on how to introduce ethics issues in the research environment, and Research Ethics courses offered at UC San Diego and partner institutions
  • Regulatory Support interacts with UC San Diego’s Human Research Protections Program (HRPP) for reporting, education, and development of Institutional Review Board (IRB) processes. A regulatory assistant helps CTRI members with proposal submissions to HRPP staff members, who ensure timely processing and regulatory review of clinical protocols through four biomedical IRBs
  • CCR Services staff assist investigators with the actual performance of clinical research involving adults and/or children. This unit provides trained clinical staff, including nurses, clinical coordinators and a nutrition consultant; clinical research space with a phase I unit and research pharmacy; sample acquisition and processing; core facilities; and data entry

Biomedical Informatics (BMI) Unit
Director: Michael Hogarth, MD

The Unit develops, pilots, launches, and manages informatics software systems, provides consultative services for investigators, and provides training in informatics in the following areas:

  • Velos eResearch is an integrated software system designed to assist investigators in managing their clinical research trials/studies. The web-based system integrates multiple tracking systems and standardizes clinical trial records, simplifying clinical trial management. It also links to the UC San Diego Health’s Epic Electronic Medical Record System to provide improved information and integration for clinical research projects. Velos eSample is a module of Velos eResearch that links biological samples to patient electronic medical records. Investigators can track where samples are stored and track multiple samples
  • REDCap, (Research Electronic Data Capture) is a secure web application for building and managing online surveys and databases. The application also allows researchers to create projects and export data to Excel, SAS, and other statistical packages. ACTRI offers training sessions and online tutorials for investigators interested in using REDCap
  • The Clinical Data Warehouse for Research (CDWR) allows researchers to identify potential research subjects through HIPAA-compliant searches of UC San Diego Medical Center patient data. The CDWR provides patient diagnoses, outpatient visits, age, and gender, among a growing list of data types
  • The UC-Research eXchange (UC-ReX) tool allows researchers to search 15 million de-identified patient records from medical center databases here at UC San Diego, as well as at UCLA, UC Irvine, UC Davis, and UC San Francisco. Launched by the University of California Biomedical Research Acceleration, Integration and Development (UC BRAID), this first cross-campus clinical query system is capable of exchanging patient-level data, as well as aggregates (counts and descriptive statistics) across the five UC medical centers and some of our key partner institutions. A Data Concierge service identifies patients for clinical research projects.

Translational Research Technology Unit (TRT)
Co-Directors: Paul Mills, PhD and Professor David Boyle

TRT provides seamless laboratory services and collaborations through the ACTRI Biorepositories, affiliated biorepositories, ACTRI Laboratory, affiliated laboratories, the ACTRI Seminar Series (with the Education unit), and educational activities.

  • The ACTRI Biorepositories prospectively collect, curate, and house human tissues and other biological samples from healthy individuals and those with selected diseases. Repository management is available to ACTRI members
  • Affiliated biorepositories include samples from patients with HIV/AIDS, cancer, neurodegenerative diseases, and rheumatic diseases
  • The ACTRI Laboratory specializes in quantitative measurement of biomarkers in human clinical specimens such as blood, solid tissue, urine, and sputum. The Laboratory offers more than 125 validated assays, many of which are immunoassays and quantitative PCR
  • Affiliated laboratories include the fMRI Center for Neuroimaging, Proteomics/Mass Spectroscopy, Tissue Imaging, the Conrad Prebys Center for Chemical Genomics, Human Tissue Resources, and the UC San Diego Genomics Core at the Sanford Consortium
  • ACTRI provides an integrated service to support molecular methods in clinical trials, and includes mentoring, training, assay design, and performance
  • ACTRI developed the Center for Accelerating Drug Development (CADD) to enable early decisions during early phases of drug development. CADD brings together the biomarker laboratory (TRT), the phase I unit (CCR) and the Center for Computational Biology and Bioinformatics.

Community Engagement (CE) Unit
Director: Howard Taras, MD

Community Engagement advances the science of community engagement in research, engages the general public on matters of clinical and translational research, and increases collaboration with community-based agencies and providers. For ACTRI investigators, research staff, and trainees, the Division promotes best practices in community engagement, increases the capacity to engage the community, and increases the use of ACTRI services.

  • Builds partnerships with practitioners and patients at Palomar Pomerado Health, Rady Children’s Hospital, community clinics, and other health-related organizations and agencies, and the general public
  • Educates the public about clinical research, translational researchers about community-based research, and community physicians about new treatments
  • Promotes research in health care disparities
  • Links investigators to potential human volunteers through novel web-based tools like ResearchMatch
  • The Participant Recruitment Center, co-established in collaboration with BMI, enhances participant recruitment for clinical trials by bringing together existing services and novel informatics platforms that consider patient preferences

Education, Training and Career Development (ETCD) Unit
Director: Colin Depp, PhD

The ACTRI ETCD Unit promotes research training by organizing institutional Roadmap training programs (i.e., KL2, CREST); developing an educational pipeline of research training: students at the undergraduate, medical, graduate, and postgraduate levels, and junior faculty; advancing mentoring through data collection and training (Mentoring Academy); leading collaborative efforts between the ETCD Division and partners at UC San Diego, other institutions, and across the CTSA Consortium; conducting research on training; and enhancing the diversity of trainees, mentors, and their projects.

  • Roadmap Clinical Research Enhancement through Supplemental Training (CREST) curriculum program: A modular curriculum that provides training in clinical research and can lead to a master’s degree
  • Roadmap KL2: A mentored research program that supports junior faculty
  • “Scholar Track” program: A five-year dual-track, concurrent MD/Masters of Advanced Science (MAS) degree program that prepares participants to launch a career in clinical research
  • Mentoring Academy: Assesses trainee and mentor needs, addresses these needs through training, and recognizes excellence in mentorship
  • ACTRI Seminar Series: The Unit supports this series aimed at clinicians, scientists, scholars and trainees at UC San Diego and our Partner/Affiliated Institutions by providing lectures and workshops on a broad range of clinical and translational research topics
  • Biomedical and Clinical Research Seminars in Hillcrest: The unit supports this series to build interactions among the faculty, staff, and trainees at UC San Diego’s Medical Center-Hillcrest; to promote collaborations with other scientists; and to stimulate an exchange of ideas
  • Increasing diversity by partnering with diversity-focused initiatives to improve outreach to underrepresented applicants

Translational Research Alliance (TRA)
Director: Deborah Spector, PhD and Murray Stein, MD, MPH

The Translational Research Alliance links clinical and translational investigators at UC San Diego, VA San Diego, Rady Children’s Hospital, and Palomar Pomerado Health with basic science researchers at the Salk Institute, the Sanford Burnham Prebys Medical Discovery Institute, the La Jolla Institute of Allergy and Immunology (LIAI), the J. Craig Venter Institute (JCVI), and San Diego State University (SDSU) in order to foster collaboration and resource-sharing, and to decrease barriers to interaction. It also facilitates technology transfer and the development of novel therapies with our partner institutions and industry, and increases interaction with CONNECT and BIOCOM.

  • Promotes collaborations among ACTRI’s institutional and corporate partners; establishes long-term relationships with multiple companies that will help develop ACTRI innovations
  • The Galvanizing Engineering in Medicine (GEM) program brings engineers and clinicians together to develop innovative technologies that can be applied to solving challenging problems in medical care. The program is a collaboration with the UC San Diego Institute of Engineering in Medicine
  • International TRA Unit promotes international research and corporate partnerships, beginning with projects in Finland, Saudi Arabia, the Netherlands, South America, and Japan
  • Pilot Research Grants offer several annual grant programs: Clinical Studies, Translational Studies, Personalized Medicine, and Innovative Technology Projects
  • William J. von Liebig Center offers consultation to pilot grant awardees on filing patents, developing business plans, seeking private funding, and other methods for commercializing university innovations. The Center is housed in the UC San Diego Jacobs School of Engineering

ACTRI Process for Service Requests

 Service Request Reviews

Funding and Facilities

ACTRI receives funding from various sources, including extramural support from the NIH through a Clinical and Translational Research Award ($52 million) and through the individual research funding of members (more than $90 million); intramural support from UC San Diego for infrastructure and education; income from recharges for services provided to members; and philanthropic and intramural support for new buildings.

In 2016, we moved into the Altman CTRI building at UC San Diego, which includes 359,000 square feet of offices, state-of-the-art laboratories and clinical space (including a research pharmacy) and houses a multitude of distinct research endeavors. All of our outpatient activities are integrated in one location, optimizing safety, oversight, and cost effectiveness. Clinical research is conducted in 18,000 square feet and includes: reception area; rooms for examination, consultation, phlebotomy, infusion, and other procedures; pharmacy; and space for sample acquisition and processing. Also located in the Altman CTRI Building are nurses and clinical coordinators, Clinical Trial Administration, the Human Research Protections Program, Biostatistics, Biomedical Informatics support, and staff for the Education and Community Divisions.

ACTRI Vouchers

UC San Diego Altman Clinical and Translational Research Institute (ACTRI) is pleased to offer vouchers for ACTRI research services. These vouchers are designed to support early-stage projects that need preliminary data for subsequent applications for federal or foundation grants and to supplement federally funded studies. They are not cash awards and can only be used for in-kind services, including those related to the clinic, biostatistics, bioinformatics, coordinator, and labs. Services are contingent upon resource availability.

To apply for a voucher, please fill out a ACTRI Voucher Request Form.


Unfunded projects that are designed to gather preliminary data for a grant submission and NIH-funded studies are eligible and the primary focus of the program. In addition, ACTRI Pilot Projects, Career Development Awards (K-series only; UC San Diego only) and ACTRI KL2 awardees are also eligible.

Vouchers can potentially be used to supplement two types of NIH-funded studies for ACTRI clinical services only.

  • Type I use the vouchers to supplement the NIH-approved funds for clinical services required for the project.
  • Type II use the vouchers to expand on the project to collect new data that will be used for renewal or new grants.

For any project requiring IRB or IACUC approval, the voucher application should be submitted in conjunction with the IRB/IACUC submission. Except for Pilot Projects and Type I NIH-funded studies, all studies involving direct patient contact will require an ACTRI Scientific Review Committee evaluation for scientific merit before granting an ACTRI voucher. Voucher applications can be submitted at any time during the year. Awarding the ACTRI voucher is contingent upon the availability of the services requested.

The ACTRI voucher amount will depend on the services being performed – see the table below. Qualified investigators are limited to one voucher in a 12-month period (grant budget period). Investigators with an awarded voucher in a budget year will have their other voucher applications rejected. Once the current year ACTRI voucher budget is expended, vouchers will not be approved. All vouchers expire on the same day as the CTSA grant budget end date, and no extensions will be granted.

PI Voucher Eligibility Guidelines:

First priority:
  • ACTRI members; currently limited to junior faculty (at assistant level, but exceptions may be made for early associate level professors). Vouchers may be opened to senior faculty pending future fund availability.
Second priority:
  • Clinicians, basic scientists, immunologists, etc. who are getting into research.
  • Associate-level professors may also qualify if funding is limited.
Third priority:
  • Grad students, PhD students, post-doc trainees, or residents that are sponsored by faculty members that meet above criteria.

Three levels of support are available:

Category A

Biostatistics and Bioinformatics services

– up to $1,000 per investigator budget year

Category B

Center for Clinical Research services

– up to $5,000 per investigator budget year

Category C

Laboratory services

– up to $5,000 per investigator budget year

Category D

Center for Computational Biology and Bioinformatics (CCBB) services

Tier 1 – up to $500 in CCBB project planning and consultation

Tier 2 – up to $10,000 in CCBB data analysis services


Category A can include ACTRI support for design, biostatics, and informatics consultation. Category B can include ACTRI clinical services: nursing services, study coordination, nutrition assistance, exercise testing, ultrasound imaging and DEXA scanning, V02 testing, phlebotomy, room only, and equipment use only. Category C can include ACTRI laboratory services: analysis and biobank.

Category D includes consultation and data analysis only, and is not for generating data.

Tier 1 includes translational medicine and systems biology brainstorming, project planning and consultation.

Tier 2 includes data analysis services (RNA-seq, ChIP-seq, DNA-seq, microbiome, network analysis, data mining, etc.


Investigators should submit an application for ACTRI Vouchers by submitting a ACTRI Voucher Request Form.

Questions about ACTRI Vouchers should be directed to the CTRI Finance Team (

Terms and Conditions for Support

ACTRI Terms and Conditions for Support


Awards may take several forms, including, but not limited to pilots and grants.

A) Responsibility of the award recipients, also known as the Principal Investigators (PIs)

  1. The pilot award is supported in whole or in part by federal funds. As a result, the PIs must follow all federal guidelines on allowable expenses, including those pertaining to NIH salary support:
  2. When making purchases for your pilot project, it is important to use the unique Oracle chart string, paying special attention to the Task Number and Project Number associated with your pilot project.
  3. No funding is permitted for travel, clerical help, office supplies, books and subscriptions, graduate student support and tuition remission, or publication expenses.
  4. PI home department procurement card charges are not allowed on ACTRI awards. However, the ACTRI Business-Finance office may use their procurement card on a case-by-case basis.
  5. All reimbursements must post during the project period and any expenditure requests made after the Expenditure Deadline for the project will be rejected. This date is found on the Award notification.
  6. It is a requirement of our CTSA award to recognize the grant supporting your effort and intellectual work in manuscript submissions and publications. To that end, you agree to include the following citation in manuscripts and/or publications that result from projects using ACTRI services: The project was partially supported by the National Institutes of Health, Grant UL1TR001442. The content is solely the responsibility of the author(s) and does not necessarily represent the official views of the NIH.
  7. If PIs overspend the awarded amount, the PIs are responsible for any deficits accumulated; PIs understand that it is their responsibility to manage the award so that no deficits will result. PIs with questions about proper spending and use of funds or have specific questions should contact the home department fund manager or the ACTRI fund manager below.

B) Responsibility of PI Home Department

  1. All services charges and costs transfers – payroll, non-payroll, and vacation credit – to use any remaining balance must be posted before the Expenditure Deadline. This date is found on the Award notification.
  2. The PI Home Department is responsible for proper and reasonable monitoring of use of funds and expenditures to ensure they comply with University policy and these Terms and Conditions.
  3. The PI Home Department will promptly notify the ACTRI if the fund it projected to, or actually, overspend; or if improper expenditures occur. The PI Home Department will correct and make adjustments to the fund as needed.
  4. The PI Home Department will contact ACTRI there are any questions or problems about allowable expenses that are permitted on the award.
  5. Any fund changes and cost transfers will be performed by the PI's home department. The PI's fund manager must obtain approval from ACTRI prior to any fund change, direct retro, or cost transfer.
  6. The PI Home Department will provide audit records promptly to ACTRI upon request. 

C) Responsibility of ACTRI

Depending on the type of award or support, ACTRI's responsibilities vary. The ACTRI has overall responsibility for managing and supporting the project's funds/expenses. ACTRI will work with the PI and Home Department to move expenses to the correct award or PI's other funding source to ensure no deficit.


A) Responsibility of the voucher recipients

  1. Vouchers may only be applied for NIH-funded or underfunded institutional research. Vouchers may not be used for industry or commercial-funded research.
  2. Voucher recipients must provide an Oracle chart string prior to utilizing ACTRI services. This includes the Task Number and Project Number associated with your project. You will be informed prior to being charged for work which exceeds your voucher.
  3. PIs are ultimately responsible for the use and spending of the funds and any billable work which exceeds the amount of the voucher.
  4. It is a requirement of our CTSA award to recognize the grant supporting your effort and intellectual work in manuscript submissions and publications. To that end, you agree to include the following citation in manuscripts and/or publications that result from projects using ACTRI services: The project was partially supported by the National Institutes of Health, Grant UL1TR001442. The content is solely the responsibility of the author(s) and does not necessarily represent the official views of the NIH.

B) Responsibility of recipient Home Department

  1. If the voucher recipient overspends and provides an invalid chart string, the Recipient's home department will apply this deficit to other department funds and may hold the Recipient responsible.

C) Responsibility of ACTRI

  1. As the voucher is fully spent, the ACTRI Business Finance team will provide accounting of hours used.


The ACTRI provides a variety of services on a recharge basis, which are often subsidized through institutional support mechanisms. The ACTRI will provide service and invoice for those services. After an invoice is issued, a PI has 60 days to contest any charges. After that, the invoice is considered accurate.

When receiveing any ACTRI service, including recharge services, please cite the grant. 

Acknowledge NIH Funding on all ACTRI Publications: The project described was partially supported by the National Institutes of Health, Grant UL1TR001442. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

Last Updated: July 27, 2023

Funding Opportunities

Pilot Project Grants

One-year competitive cash awards to obtain preliminary data. Funding priority is given to early-career faculty members. Several award categories are offered. Calls for proposals occur annually. Click here for more information

Galvanizing Engineering in Medicine (GEM)

is a collaboration between UC San Diego Altman Clinical and Translational Research Institute (ACTRI) and the Institute of Engineering in Medicine (IEM). GEM projects identify clinical challenges for which engineering solutions can be developed and implemented to improve health care ($50,000 to $100,000 for up to 18 months). These competitive awards are intended to leverage UC San Diego's strengths in clinical care and engineering. Calls for proposals occur at least annually. Click here for more information


The ACTRI KL2 Grant Support program is a research training grant for junior faculty, provides up to three years of research career development support and up to $120,000 for UC San Diego instructors or assistant professors. Click here for more information

Diversity Supplement Awards

Click here for more information

The Health Sciences Office of Faculty Affairs has many resources on their website as well.